A colonoscopy is a procedure where a doctor uses a flexible camera to examine the inside of your colon. Most start as a diagnostic colonoscopy (45378). If polyps or abnormal tissue are found during the exam, the doctor removes them on the spot — which upgrades the billing code to 45380 (biopsy) or 45385 (polyp removal). You generally won't know which code you'll be billed for until after the procedure.
| Code | Variant | When it applies | |
|---|---|---|---|
| CPT 45378 | Diagnostic | Camera exam only, nothing found or removed | See exact rates → |
| CPT 45380 | With biopsy | Tissue sample taken for lab testing | See exact rates → |
| CPT 45385 | With polyp removal | Polyp found and removed during exam | See exact rates → |
Ranges span all billing codes for this procedure. Actual rate depends on which variant is performed.
| Insurance | AdventHealth Tampa | AdventHealth Wesley Chapel | AdventHealth Zephyrhills | HCA Florida Brandon Hospital | HCA Florida Largo Hospital | HCA Florida South Tampa Hospital | HCA Florida Trinity Hospital | HCA Florida West Tampa Hospital |
|---|---|---|---|---|---|---|---|---|
| Workers Comp | — | — | — | $1,635–$2,816Best | $1,635–$2,816Best | $1,635–$2,816Best | $1,635–$2,816Best | $1,635–$2,816Best |
| Molina | $705Best | $705Best | $705Best | $2,326 | $2,326 | $2,326 | $2,326 | $2,326 |
| Humana | $871–$1,124Best | $2,848–$3,747 | $2,076–$2,720 | — | — | — | — | — |
| Blue Cross Blue Shield | — | — | — | $1,894–$2,606Best | $1,894–$2,606Best | $2,480–$3,359 | $2,473–$3,802 | $2,480–$3,359 |
| Aetna | $2,506–$3,298Best | $3,131–$4,119 | $3,191–$4,198 | — | — | — | — | — |
| Oscar Health | $1,694–$2,188Best | $1,758–$2,270 | $1,929–$2,490 | $3,662 | $3,662 | $3,662 | $3,662 | $3,662 |
| Cigna | $2,455–$3,218 | $2,117–$2,774Best | $2,145–$2,811 | $7,480 | $7,480 | $7,480 | $7,480 | $7,480 |
| Multiplan | $6,936–$9,125Best | $8,046–$10,585 | $8,046–$10,585 | — | — | — | — | — |
Source: Hospital price transparency files (federally required). Facility fees only.
Each hospital negotiates separate contracts with every insurer. For the same procedure, the rate can differ by 3–5x between hospital systems — larger systems have more leverage and command higher rates.